Key result
Two patients with pulmonary veno-occlusive disease presented atypically with severe hypoxaemia and low diffusion capacity, lacking pulmonary hypertension and classical imaging findings.
Case Report (n=2)
Pulmonary veno-occlusive disease should be included in the differential diagnosis of unexplained hypoxemia, even without pulmonary hypertension.
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Severe hypoxemia without PH may indicate atypical PVOD; leaves open expanded differentials pending prospective validation.
Pulmonary veno-occlusive disease is an uncommon condition that typically presents with moderate to severe pulmonary hypertension and characteristic imaging abnormalities. We report two patients who presented with severe hypoxaemia and low diffusion capacity without pulmonary hypertension and classical imaging findings. Pulmonary venoocclusive disease should be included in the differential diagnosis of unexplained hypoxemia.
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Hatipoğlu et al. (2025) conducted a case report in Pulmonary veno-occlusive disease (n=2). Two patients with pulmonary veno-occlusive disease presented atypically with severe hypoxaemia and low diffusion capacity, lacking pulmonary hypertension and classical imaging findings.
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