Population
Human L-type cardiac calcium channel model
Comparison
Site-directed mutagenesis replacing Glu residues… vs Wild-type human cardiac calcium channels
Design
Preclinical
Authors
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Highlights key residues for Ca²⁺ selectivity in cardiac L-type channels; extends biophysical knowledge but leaves open therapeutic implications in humans.
Identifies specific glutamate residues in the pore-lining region that are critical for the ion selectivity of human cardiac L-type calcium channels.
Tang et al. (1993) studied this question.
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