March 1, 1992The Journal of General PhysiologyOpen Access

Calcium currents in the A7r5 smooth muscle-derived cell line. An allosteric model for calcium channel activation and dihydropyridine agonist action.

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Population

A7r5 smooth muscle-derived cell line

Comparison

Dihydropyridine (DHP) calcium channel agonists vs Absence of DHP agonists

Design

Preclinical

Authors

TMTatjana MarksHealth Foundation SJSarah JonesManchester Metropolitan University

Discussion

Member takes

Implication

Does not inform clinical DHP use; leaves open validation of the modified MWC model in human channels.

Structured PICO

Population

A7r5 smooth muscle-derived cell line

Intervention

Dihydropyridine (DHP) calcium channel agonists

Comparator

Absence of DHP agonists

Outcome

Gating kinetics of calcium channels (single channels and whole cell currents)surrogate

Proposes a modified Monod-Wyman-Changeux model for calcium channel activation where DHP agonists act as allosteric effectors stabilizing the open states.

Cite This Study

Marks et al. (1992) studied this question.

synapsesocial.com/papers/6a7072425d37378ac1dd8985 https://doi.org/10.1085/jgp.99.3.367

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Calcium currents in the A7r5 smooth muscle-derived cell line. An allosteric model for calcium channel activation and dihydropyridine agonist action.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calcium currents in the A7r5 smooth muscle-derived cell line. An allosteric model for calcium channel activation and dihydropyridine agonist action.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider