Key result
Intracerebroventricular injection of Buthus lienhardi scorpion venom in rats induced dose-dependent effects, resulting in death at high doses (5.4 and 8.1 µg/kg) and organ damage at lower doses.
Why the study?
The study assessed the relationship between the amount of scorpion venom in the central nervous system and the severity of envenomation symptoms.
Does intracerebroventricular injection of Buthus lienhardi scorpion venom induce dose-dependent severity of symptoms in rats?
Does intracerebroventricular injection of Buthus lienhardi scorpion venom induce dose-dependent severity of symptoms in rats?
Intracerebroventricular injection of Buthus lienhardi scorpion venom in rats induces dose-dependent systemic toxicity, including myocardial and pulmonary damage, and death at high doses.
Rat venom model shows central neurotoxicity; leaves open translation to human envenomation mechanisms or therapies.
Rats animal model was used to assess the severity of symptoms produced following the Intracerebroventricular injection (ICV) of incremental doses of Buthus lienhardi scorpion venom based on histopathological, biochemical, and hematological analyses. Our results show that the ICV injection of incremental doses of scorpion venom induced a dose-dependent effects resulting in death when high doses were administrated (5.4 and 8.1 µg/kg). Moreover, ICV administration of lower doses of B. lienhardi (0.27 and 2.7 µg/kg) produced marked myofibrillar degeneration, while lungs showed intra-alveolar hemorrhage. Concomitantly, there was a significant rise in the serum levels of AST, ALT, CPK, LDH, urea, and creatinine.
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Laaradia et al. (2019) studied Scorpion envenomation. Buthus lienhardi scorpion venom was evaluated on Severity of symptoms (histopathological, biochemical, and hematological analyses). Intracerebroventricular injection of Buthus lienhardi scorpion venom in rats induced dose-dependent effects, resulting in death at high doses (5.4 and 8.1 µg/kg) and organ damage at lower doses.
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