What question did this study set out to answer?

To determine whether surgical clearance margins during penectomy can be safely reduced based on tumor grade to preserve cosmetic and functional outcomes without increasing local recurrence.

February 1, 2000BJU International

The histological extent of the local spread of carcinoma of the penis and its therapeutic implications

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Authors

AAAmit AgrawalUniversity of Cambridge DPDinker PaiSri Balaji Vidyapeeth University NAN AnanthakrishnanMahatma Gandhi Medical College and Research Institute

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Implication

Pathological study demonstrates microscopic spread extends up to 10 mm in penile carcinoma, suggesting surgical margins can be safely reduced to preserve tissue.

Key Points

To determine whether surgical clearance margins during penectomy can be safely reduced based on tumor grade to preserve cosmetic and functional outcomes without increasing local recurrence.
Evaluated surgical specimens from 64 patients who underwent partial or total penectomy for penile carcinoma.
Analyzed serial proximal 5-mm tissue sections histologically to measure microscopic tumor extension beyond visible gross margins.
Correlated histological grade with anatomical site, tumor morphology, and proximal microscopic spread using the chi-squared test.
Tumors were classified as grade 1 (31%), grade 2 (50%), and grade 3 (19%), with higher-grade lesions showing significantly greater involvement of the penile shaft.
Maximum proximal microscopic tumor spread was 5 mm for grade 1 and grade 2 lesions and 10 mm for grade 3 lesions, with no discontinuous spread observed.

Cite This Study

Agrawal et al. (2000) studied this question.

synapsesocial.com/papers/6a7072b86ceb2bbd16dfe432 https://doi.org/10.1046/j.1464-410x.2000.00413.x

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Implication

Pathological study demonstrates microscopic spread extends up to 10 mm in penile carcinoma, suggesting surgical margins can be safely reduced to preserve tissue.

The histological extent of the local spread of carcinoma of the penis and its therapeutic implications

Discussion

Member takes

Implication

Key Points

Cite This Study

The histological extent of the local spread of carcinoma of the penis and its therapeutic implications

Discussion

Member takes

Implication

Key Points

Cite This Study

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