Population
37 normotensive Long-Evans rats (n=19 sinoaortic baroreceptor denervation, n=18 sham-operated)
Comparison
Sinoaortic baroreceptor denervation (SAD) vs Sham operation
Design
Preclinical
Follow-up
6 weeks
Authors
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Rat data linking baroreflex loss to hypertrophy via variability should not change practice; hypothesis-generating for human cardiac remodeling.
Sinoaortic baroreceptor denervation in rats leads to increased blood pressure variability and significant biventricular hypertrophy at 6 weeks.
Vliet et al. (1996) studied this question.
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