Why the study?
Does antihypertensive treatment with captopril, clonidine, hydralazine, metoprolol, or prazosin modify circadian blood pressure and heart rate variability in spontaneously hypertensive rats?
Does antihypertensive treatment with captopril, clonidine, hydralazine, metoprolol, or prazosin modify circadian blood pressure and heart rate variability in spontaneously hypertensive rats?
Sympatholytic antihypertensive agents (clonidine, prazosin, metoprolol) modify circadian BP and HR rhythms in spontaneously hypertensive rats, whereas nonsympatholytic vasodilators (hydralazine, captopril) do not.
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Sympatholytics may modulate circadian BP/HR variability in rat models; leaves open translation to human hypertension management.
Janssen et al. (1991) studied this question.
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