Impact of high-sensitivity cardiac troponin I assay imprecision on the safety of a single-sample rule-out approach for myocardial infarction

Figure 1:. Estimated proportion of patients with suspected acute coronary syndrome reclassified due to hs-cTnI assay imprecision at the rule-out threshold of <5 ng/L and likelihood of MI or myocardial injury in those misclassified as a proportion of the total number of patients at each measured cardiac troponin concentration. (A) Proportion reclassified as higher risk by assay imprecision (%). (B) Proportion reclassified as lower risk by assay imprecision (%). (C) Overall proportion reclassified by imprecision (%). (D) Likelihood of MI in those incorrectly classified as lower risk by imprecision (%). (E) Likelihood of myocardial injury in those incorrectly classified as lower risk by imprecision (%). Patients with STEMI (n=925) were excluded from the modelling.