Total Analytic Error for Low Cardiac Troponin Concentrations (≤10 ng/L) by Use of a High-Sensitivity Cardiac Troponin Assay
Key result
An evaluation of approximately 10 fresh samples per lot comparison was conducted over 2 years to establish total analytic error for Abbott hs-cTnI concentrations ≤10 ng/L.
Population
Blood samples containing cardiac troponin concentrations spanning the measuring range, including samples…
Comparison
High-sensitivity cardiac troponin assay (Abbott) vs Different lots of reagents/calibrators
Design
Editorial
Authors
Discussion
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Implication
Establishing a total analytic error criterion for low concentrations of high-sensitivity cardiac troponin helps identify problematic reagent lots and suboptimal analyzer performance.
Structured PICO
P
Population
Fresh samples with cardiac troponin concentrations spanning the measuring range, evaluated over a 2-year period to assess lot-to-lot variation.
E
Exposure
High-sensitivity cardiac troponin assay (Abbott)
C
Comparator
Different lots of reagents/calibrators
O
Outcome
Total analytic error (TAE), concentration biases, and imprecision at low cTn concentrations (≤10 ng/L)surrogate
Establishing a total analytic error criterion for low concentrations of high-sensitivity cardiac troponin helps identify problematic reagent lots and suboptimal analyzer performance.
Cite This Study
Kavsak et al. (2017) conducted a letter in Low cardiac troponin concentrations. Abbott high-sensitivity cardiac troponin assay vs. Different lots of reagents/calibrators was evaluated on Total analytic error (TAE) for cTnI concentrations ≤10 ng/L. An evaluation of approximately 10 fresh samples per lot comparison was conducted over 2 years to establish total analytic error for Abbott hs-cTnI concentrations ≤10 ng/L.