Key result
Recalibration of a high-sensitivity cardiac troponin T assay resulted in an upward shift in concentrations, decreasing the proportion of undetectable results (<5 ng/L) from 30.2% to 1.9%.
Why the study?
Does the recalibration of the hs-cTnT assay alter the measured troponin concentrations in elderly patients?
Population
311 elderly patients, median age 81.5 years
Comparison
High-sensitivity cardiac troponin T measurement… vs hs-cTnT measurement using former nonrecalibrated…
Design
Editorial
Authors
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Recalibration of the Roche hs-cTnT assay introduces a positive bias of approximately 6 ng/L at low concentrations, which will dramatically decrease the percentage of undetectable results and may impact clinical classification.
Does the recalibration of the hs-cTnT assay alter the measured troponin concentrations in elderly patients?
Absolute Event Rate: 1.9% vs 30.2%
Recalibration of the Roche hs-cTnT assay introduces a positive bias of approximately 6 ng/L at low concentrations, which will dramatically decrease the percentage of undetectable results and may impact clinical classification.
Kuster et al. (2013) conducted a letter in Elderly patients (n=311). Recalibrated hs-cTnT assay (lot 167650) vs. Former nonrecalibrated hs-cTnT assay (lot 164776) was evaluated on Percentage of results below the limit of detection (<5 ng/L). Recalibration of a high-sensitivity cardiac troponin T assay resulted in an upward shift in concentrations, decreasing the proportion of undetectable results (<5 ng/L) from 30.2% to 1.9%.
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