Key result
In patients with significant mitral regurgitation and severe left ventricular dysfunction, mitral valve surgery resulted in an acceptable in-hospital mortality of 10% and significantly improved left ventricular ejection fraction from 27.9% to 37.6% at one year.
Why the study?
Does mitral valve surgery improve survival and left ventricular function in patients with significant mitral regurgitation and severe left ventricular systolic dysfunction (LVEF ≤30%)?
Cohort (n=40)
Does mitral valve surgery improve survival and left ventricular function in patients with significant mitral regurgitation and severe left ventricular systolic dysfunction (LVEF ≤30%)?
Absolute Event Rate: 37.6% vs 27.9%
p-value: p=<0.01
Mitral valve surgery in high-risk patients with severe left ventricular dysfunction (LVEF ≤30%) is associated with acceptable mortality, significant reverse remodeling, and improved quality of life.
May support mitral valve surgery in selected patients; leaves open survival benefit versus medical therapy in randomized trials.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Šetina et al. (2008) conducted a cohort in Mitral valve regurgitation with severe left ventricular systolic dysfunction (n=40). Mitral valve surgery (repair or replacement) vs. Baseline (preoperative) was evaluated on Left ventricular ejection fraction at 1 year (p=<0.01). In patients with significant mitral regurgitation and severe left ventricular dysfunction, mitral valve surgery resulted in an acceptable in-hospital mortality of 10% and significantly improved left ventricular ejection fraction from 27.9% to 37.6% at one year.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: