Key result
Stent-mounted aortic bioprosthesis implantation significantly decreased left ventricular septal thickness in diastole from 14.84 mm to 13.92 mm at six months postoperatively (p < 0.0001).
Why the study?
Does implantation of stent-mounted aortic bioprostheses with suboptimal effective orifice area reduce left ventricular hypertrophy in patients with aortic stenosis?
Cohort (n=293)
No
Does implantation of stent-mounted aortic bioprostheses with suboptimal effective orifice area reduce left ventricular hypertrophy in patients with aortic stenosis?
Absolute Event Rate: 13.92% vs 14.84%
p-value: p=<0.0001
Stent-mounted aortic bioprostheses lead to significant regression of left ventricular hypertrophy at 1 year despite suboptimal indexed effective orifice areas (patient-prosthesis mismatch).
Supports LVH regression despite PPM; hypothesis-generating and requires prospective validation.
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Šantavý et al. (2008) conducted a cohort in Aortic stenosis (n=293). Stent-mounted bioprosthesis implantation vs. Pre-operative baseline was evaluated on Septal thickness in diastole at 6 months (mm) (p=<0.0001). Stent-mounted aortic bioprosthesis implantation significantly decreased left ventricular septal thickness in diastole from 14.84 mm to 13.92 mm at six months postoperatively (p < 0.0001).
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