Key result
Postoperative complications following curative resection of non-metastatic colorectal cancer predicted significantly worse overall survival (HR 1.36).
Why the study?
Post-surgical complications are widespread after curative resection of non-metastatic colorectal cancer, but data on their impact on long-term oncological outcomes remain controversial.
Does the occurrence of postoperative complications worsen overall survival, disease-free survival, and recurrence in patients undergoing curative resection of non-metastatic colorectal cancer?
Systematic Review (n=37,192)
Does the occurrence of postoperative complications worsen overall survival, disease-free survival, and recurrence in patients undergoing curative resection of non-metastatic colorectal cancer?
Hazard Ratio: 1.36 (95% CI 1.15–1.61)
p-value: p=<0.00001
Postoperative complications following curative resection of stage I-III colorectal cancer are significantly associated with worse overall survival, disease-free survival, and increased recurrence.
Postoperative complications warrant closer surveillance after colorectal cancer resection; leaves open whether prevention improves survival.
Background and objective The incidence of post-surgical complications (PSCs) after curative resection of non-metastatic colorectal cancer (CRC) is very widespread and evident. Some studies suggest that PSCs often predict poor long-term oncological outcomes. However, the available data on the topic is often controversial. The aim of this systematic review and meta-analysis was to study the effect of postoperative complications (POCs) on long-term oncological outcomes following curative resection of non-metastatic (stage I-III) CRC. Methods A comprehensive search of MEDLINE® and Excerpta Medica dataBASE (EMBASE) databases was performed via the Ovid platform, by using controlled vocabulary as well as natural language terms for POCs, outcomes, and CRC. Two authors independently screened the studies and extracted data. Conflicts were resolved by discussion among authors and also independently with the help of a third author. Meta-analysis was performed using a random-effects model (REM) to calculate pooled estimates for overall survival (OS), disease-free survival (DFS), and overall recurrence. Results Overall, 3,836 studies were initially screened, and 16 studies involving 37,192 patients were ultimately selected for final inclusion in the analysis. Meta-analysis of these studies showed that PSCs following non-metastatic CRC surgery predicted worse OS rates [hazard ratio (HR): 1.36; 95% CI: 1.15-1.61; p<0.00001], DFS (HR: 1.41; 95% CI: 1.11-1.80; p<0.00001), and overall recurrence (HR: 1.19; 95% CI: 1.04-1.37; p=0.01). Conclusion Based on our findings, PSCs predict poor OS rates, DFS, and overall recurrence following curative resection of non-metastatic CRC.
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Mualla et al. (2021) conducted a systematic review in Non-metastatic colorectal cancer (Stage I-III) (n=37,192). Postoperative complications vs. No postoperative complications was evaluated on Overall survival (HR 1.36, 95% CI 1.15-1.61, p=<0.00001). Postoperative complications following curative resection of non-metastatic colorectal cancer predicted significantly worse overall survival (HR 1.36).
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