Key result
Numerical simulations of the acute phase of myocardial infarction modeled the trigger mechanisms of rapid myocardial damage and evaluated the effectiveness of anti-inflammatory cytokine strategies.
Numerical simulations of acute myocardial infarction successfully modeled the inflammatory phase and cell death dynamics, providing a framework for evaluating anti-inflammatory therapies.
The dynamics of death of cardiac muscle cells in the acute phase of myocardial infarction is studied numerically. The problem is considered in local and spatially distributed formulations. The adequacy of the mathematical model is confirmed by the quantitative agreement between the results of numerical solution of the problem and experimental data. The adopted models are used to investigate the trigger mechanism of transition from a favorable scenario for the development of acute myocardial infarction to a scenario with a rapid increase in the level of myocardial damage on the third–fifth day of myocardial infarction. For these scenarios of the development of myocardial infarction, the process of demarcating inflammation is investigated. The results of the studies, including evaluations of the effectiveness of anti-inflammatory cytokine therapeutic strategies, are consistent with available data of laboratory studies.
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Воропаева et al. (2021) studied Acute myocardial infarction. Anti-inflammatory cytokine therapeutic strategies (numerical simulation) was evaluated on Dynamics of death of cardiac muscle cells and process of demarcating inflammation. Numerical simulations of the acute phase of myocardial infarction modeled the trigger mechanisms of rapid myocardial damage and evaluated the effectiveness of anti-inflammatory cytokine strategies.
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