A synthesis of some 1,2-(hetero)arylsubstituted ethanone and 1,3(hetero)aryl substituted 3-hydroxypropenone derivatives, designed as potential HIV-1 integrase inhibitors, is reported. The microwave-assisted synthesis was applied in several reactions achieving reductions in reaction times and high yields. All compounds prepared were tested to explore their potential anti-HIV activity.
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Monforte et al. (2004) studied this question.
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