Recent Trends in the Synthesis of Enaminones

Enaminones are very useful intermediates for building different categories of heterocyclic compounds.Formation of enaminone derivatives was achieved using a variety of compounds such as alcohols, aldehydes, active methyl ketones, active methylene ketones, -alkoxy ketones, -diketones, acetoacetamides, Grignard reagents, diazocarbonyl compounds, acetylene derivatives, nitrile derivatives, cyclic compounds, acyl chloride and other enaminones.The present review covers the methods developed for the synthesis of enaminone derivatives. CONTENTS1. Introduction 2. Synthesis of enaminones 2.1.From alcohols 2.2.From aldehydes 2.3.From active methyl ketones 2.4.From active methylene ketones 2.5.From -alkoxy ketones 2.6.From -diketones 2.7.From acetoacetamides 2.8.From Grignard reagents 2.9.From diazocarbonyl compounds 2.10.From acetylene derivatives 2.11.From nitrile derivatives 2.12.From cyclic compounds 2.13.From other enaminones 3. Synthesis of bis-enaminones 3.1.From -alkoxy ketones 3.2.From -diketones 3.3.From -ketoesters 3.4.From acyl chloride 3.5.From other enaminones 4. Conclusion 5. References