Antioxidants play an essential role in preventing oxidative stress.In this study, we synthesized novel tocopherol analogs with heterocyclic rings such as quinoline ( 5), indole (6), and benzimidazole (7), and evaluated their radical scavenging activities.The results showed that 6 has excellent radical scavenging activity.The data suggested that radical scavenging activity was enhanced in compounds containing heterocyclic rings with sufficient -electrons and decreased in compounds with heterocyclic rings deficient -electrons.
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Okayama et al. (2023) studied this question.
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