What question did this study set out to answer?

To evaluate the impact of various quinolone antibiotic derivatives on the metabolic and total body clearance of theophylline in patients with chronic obstructive airways disease.

December 1, 1986British Journal of Clinical PharmacologyOpen Access

The influence of quinolone derivatives on theophylline clearance.

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Authors

WWWJ WijnandsRadboud University Nijmegen TVT. B. VreeRadboud University Nijmegen CHCL Van HerwaardenRadboud University Nijmegen

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Implication

Comparative study reveals differential reduction of theophylline clearance by specific quinolones in patients with airways disease, indicating metabolite-driven drug interactions.

Key Points

To evaluate the impact of various quinolone antibiotic derivatives on the metabolic and total body clearance of theophylline in patients with chronic obstructive airways disease.
Conducted a comparative pharmacokinetic evaluation measuring plasma theophylline concentrations and clearance rates during co-administration with various quinolone derivatives.
Tested interactions across multiple agents including enoxacin, pefloxacin, ciprofloxacin, ofloxacin, and nalidixic acid.
Co-administration significantly increased plasma theophylline concentrations with enoxacin (+110.9%), ciprofloxacin (+22.8%), and pefloxacin (+19.6%).
Total body theophylline clearance decreased by 63.6% with enoxacin, 30.4% with ciprofloxacin, and 29.4% with pefloxacin, whereas ofloxacin and nalidixic acid caused no pharmacokinetic changes.
Findings suggest the clearance inhibition is primarily driven by the active 4-oxo metabolite of enoxacin, pefloxacin, and ciprofloxacin rather than the parent compounds.

Cite This Study

Wijnands et al. (1986) studied this question.

synapsesocial.com/papers/6a70757c2fdcb5703edb5eec https://doi.org/10.1111/j.1365-2125.1986.tb02957.x

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Implication

Comparative study reveals differential reduction of theophylline clearance by specific quinolones in patients with airways disease, indicating metabolite-driven drug interactions.

The influence of quinolone derivatives on theophylline clearance.

Discussion

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Implication

Key Points

Cite This Study

The influence of quinolone derivatives on theophylline clearance.

Discussion

Member takes

Implication

Key Points

Cite This Study

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