Why the study?
Does oxandrolone improve post-heparin lipase activity and serum triglycerides in patients with familial hyperchylomicronemia?
Does oxandrolone improve post-heparin lipase activity and serum triglycerides in patients with familial hyperchylomicronemia?
Oxandrolone normalizes post-heparin lipase activity but fails to reduce serum triglycerides in familial hyperchylomicronemia, suggesting the PHLA increase does not correct the underlying chylomicron-clearing deficiency.
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Oxandrolone may normalize PHLA without lowering triglycerides in familial hyperchylomicronemia; single case leaves open any therapeutic role.
The very low post-heparin lipase activity (PHLA) and the hypertriglyceridemia of familial hyperchylomicronemia have previously been found unresponsive to drug therapy. In this study, 2 siblings with the disease were treated with oxandrolone 7.5 mg daily during the last week of a 2-week hospital admission. PHLA was normalized during treatment, but serum triglycerides were unaffected. We suggest that the increase of PHLA does not signify a correction of the deficiency in the chylomicron-clearing mechanism of these patients.
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Færgeman et al. (1973) studied this question.
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