Key result
The leader proteins of TMEV and Mengo virus are functionally interchangeable in their ability to inhibit host antiviral responses despite significant sequence divergence.
Cardiovirus leader proteins are functionally interchangeable across strains and have evolved to adapt to the specific replication fitness of the viruses while maintaining the ability to suppress host immune responses.
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Hypothesis-generating in rodent models; leaves open translation to human cardiovirus pathogenesis or therapies.
Paul et al. (2006) studied Cardiovirus infection. Chimeric viruses exchanging L-coding regions vs. Wild-type viruses was evaluated on Virus replication and inhibition of host antiviral responses. The leader proteins of TMEV and Mengo virus are functionally interchangeable in their ability to inhibit host antiviral responses despite significant sequence divergence.
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