Population
Baby hamster kidney cells (BHK-21) and mouse fibroblasts (L929 cells)
Comparison
Mengovirus leader peptide deletion mutant vs Wild-type mengovirus
Design
Preclinical
Follow-up
8 h postinfection
Authors
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Supports leader peptide role in host shutoff; leaves open in vivo relevance and therapeutic targeting in cardiovirus infections.
The cardiovirus leader peptide is involved in the inhibition of host cell protein synthesis.
Zoll et al. (1996) studied this question.
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