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This communication provides a complete rebuttal to claims by Kreutz et al. regarding the methods and findings of the Hygia Chronotherapy Trial.
The authors provide a rebuttal defending the methodology and findings of the Hygia Chronotherapy Trial against criticisms from the European Society of Hypertension.
Reinhold Kreutz and colleagues in a recent editorial claim the Hygia Chronotherapy Trial lacks credibility because of deficient methods, thereby dismissing both the plausibility and clinical significance of its reported findings. They misstate and misrepresent crucial information, findings and conclusions unambiguously detailed in the published report of the Hygia Chronotherapy Trial. The purpose of this communication is to provide a complete rebuttal to each and every one of the misleading and scientifically unsupported claims by Kreutz et al. that calls into question their expertise to decry the merits, advantages, limitations and validity of correctly designed and conducted ambulatory blood pressure monitoring-based chronotherapy trials.
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Crespo et al. (2020) conducted a letter in Hypertension. Bedtime hypertension chronotherapy was evaluated. This communication provides a complete rebuttal to claims by Kreutz et al. regarding the methods and findings of the Hygia Chronotherapy Trial.