Why the study?
Do K+ ATP-channel openers cause pro-arrhythmic effects in the setting of acute myocardial ischemia?
Do K+ ATP-channel openers cause pro-arrhythmic effects in the setting of acute myocardial ischemia?
The risk of pro-arrhythmia from K+ ATP-channel openers in ischemic heart disease may be overestimated, as it primarily occurs at high doses causing electrophysiologic inhomogeneity.
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K+ ATP openers may pose lower pro-arrhythmic risk in acute ischemia than feared at clinical doses; leaves open dose-stratified arrhythmia trials.
Arthur A.M. Wilde (1994) studied this question.
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