Population
104 unrelated Caucasian multiple sclerosis (MS) patients and 108 controls
Comparison
Sequential restriction fragment length… vs 108 controls not matched for DR type
Design
Case-control
Authors
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HLA class II haplotypes associate with MS susceptibility and resistance; leaves open replication and functional validation before clinical use.
Identified specific HLA class II gene haplotypes associated with susceptibility and resistance to multiple sclerosis, as well as potential correlations with clinical course.
Haegert et al. (1990) studied this question.
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