Key result
Calmodulin interacts with voltage-gated sodium channels to modulate gating and trafficking, and mutations in the CaM-binding IQ domain are associated with epilepsy, autism, and arrhythmias.
Design
Review
Authors
Loading...
CaM-IQ variants should not yet alter management; extends molecular links across epilepsy, autism, and arrhythmia syndromes.
Provides a comprehensive overview of calmodulin's interaction with voltage-gated sodium channels and the pathophysiological consequences of IQ domain mutations, such as arrhythmias.
Xin et al. (2021) conducted a review in Epilepsy, autism, and arrhythmias. Calmodulin (CaM) interactions was evaluated. Calmodulin interacts with voltage-gated sodium channels to modulate gating and trafficking, and mutations in the CaM-binding IQ domain are associated with epilepsy, autism, and arrhythmias.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: