Population
Alkali-dedifferentiated Madin-Darby canine kidney-C7 focus cells and parental epithelial MDCK-C7 cells
Comparison
Alkali-induced dedifferentiation and serum… vs Parental epithelial MDCK-C7 cells and untreated…
Design
Preclinical
Authors
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Supports distinct ERK1/ERK2 functions in renal epithelial dedifferentiation; leaves open validation in animal models of kidney injury.
The study demonstrates distinct signaling functions of ERK1 and ERK2 associated with alkali-induced stable MDCK-C7 cell dedifferentiation.
Schramek et al. (1997) studied this question.
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