Why the study?
Does autonomic blockade and positional change affect the beat-to-beat adaptation of ventricular repolarization to cardiac cycle length in healthy subjects?
Does autonomic blockade and positional change affect the beat-to-beat adaptation of ventricular repolarization to cardiac cycle length in healthy subjects?
System identification techniques can characterize the cycle dependence of ventricular repolarization, demonstrating significant modulation by posture and sympathetic tone.
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Postural and sympathetic modulation of repolarization adaptation warrants caution during orthostatic assessment; leaves open translation to patients with repolarization disorders.
Raeder et al. (1995) studied this question.
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