Why the study?
Does antipsychotic treatment increase overall and cardiovascular mortality in patients with schizophrenia?
Population
22,722 individuals in Sweden with schizophrenia, including 21,492 diagnosed before 2006 and 1,230 with…
Comparison
Antipsychotic treatment, categorized by… vs No antipsychotic exposure and age- and…
Design
Cohort
Follow-up
January 2006 to December 2010
Authors
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Antipsychotic non-use linked to highest mortality in schizophrenia; leaves open confounding and need for RCTs before changing practice.
Does antipsychotic treatment increase overall and cardiovascular mortality in patients with schizophrenia?
In patients with schizophrenia, cumulative antipsychotic exposure displays a U-shaped curve for mortality, with the highest risk of death among those with no antipsychotic use, suggesting excess cardiovascular mortality is not primarily attributable to adequate antipsychotic treatment.
Torniainen et al. (2014) studied this question.
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