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A cationic iridium‐catalyzed C‐7 alkylation of N ‐substituted indoline derivatives with various alkenes has been developed. A variety of 7‐alkylindolines were obtained in moderate to high yields. This protocol relies on the use of the carbonyl group on the nitrogen atom of indoline as a directing group and it is potentially applicable to the large‐scale synthesis of 7‐alkylindoles. magnified image
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Pan et al. (2014) studied this question.
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