Human HSP70 promoter contains at least two distinct regulatory domains.
Structured PICO
P
Population
Human HSP70 gene promoter constructs in stable transfectants
I
Intervention
Dissection of sequences upstream of the transcription start site using chimeric genes fused to chloramphenicol acetyltransferase
O
Outcome
Transcription levels determined by S1 nuclease analysis in response to heat shock, cadmium, and serum stimulationsurrogate
The human HSP70 promoter is regulated by distinct domains for stress (heat shock/cadmium) and nonstress (serum) conditions.
Authors
Discussion
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Implication
May enable selective HSP70 modulation under stress versus growth conditions; leaves open translation to human cardiovascular therapies.
Cite This Study
Wu et al. (1986) studied this question.