Key result
Coronary artery bypass grafting was not associated with significant new ischemic brain lesions on MRI or significant cognitive decline at 6 to 12 weeks postoperatively.
Why the study?
To evaluate new brain lesions on MRI-DWI in patients undergoing CABG and determine their relationship with neurocognitive outcomes.
Does coronary artery bypass grafting (CABG) cause new brain MRI-DWI lesions that correlate with neurocognitive outcomes in patients aged 30-65 years?
Population
66 patients undergoing CABG
Comparison
Pre-operative vs post-operative evaluation
Design
Prospective study
Follow-up
6-12 weeks
Authors
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New DWI lesions may flag higher cognitive decline risk post-CABG; hypothesis-generating and requires prospective validation before practice change.
Observational (n=66)
Single-blind
No
Does coronary artery bypass grafting (CABG) cause new brain MRI-DWI lesions that correlate with neurocognitive outcomes in patients aged 30-65 years?
Absolute Event Rate: 15.15% vs 13.64%
In patients undergoing CABG, there appears to be no significant correlation between post-operative cognitive dysfunction and objective evidence of new structural ischemia on MRI-DWI at 6-12 weeks.
Renu Khamesra (2023) conducted an observational in Coronary artery disease requiring CABG (n=66). Coronary artery bypass grafting (CABG) vs. Pre-operative baseline was evaluated on Moderate or severe degree of neuropsychological dysfunction. Coronary artery bypass grafting was not associated with significant new ischemic brain lesions on MRI or significant cognitive decline at 6 to 12 weeks postoperatively.
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