January 1, 2000Pathophysiology of Haemostasis and Thrombosis

Absence of Transplacental Passage of the Low Molecular Weight Heparin Enoxaparin

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Why the study?

Does enoxaparin cross the placenta in pregnant women?

Population

24 pregnant women undergoing early termination of pregnancy due to major fetal malformations

Comparison

Enoxaparin 40 mg vs 10 pregnant women not receiving enoxaparin

Design

Cohort

Authors

CDConstantine DimitrakakisNational and Kapodistrian University of Athens PPPanayiotis PapageorgiouUniversity of Peloponnese IPIoannis PapageorgiouUniversity of Cambridge

Discussion

Member takes

Implication

Supports enoxaparin safety for VTE prevention in pregnancy; leaves open confirmation in larger prospective studies.

Structured PICO

Does enoxaparin cross the placenta in pregnant women?

Population

24 pregnant women undergoing early termination of pregnancy due to major fetal malformations

Intervention

Enoxaparin 40 mg

Comparator

10 pregnant women not receiving enoxaparin (implied)

Outcome

Anti-IIa and anti-Xa activities in fetal and maternal blood samplessurrogate

Enoxaparin does not cross the placenta, supporting its safety for the fetus when used for VTE prevention during pregnancy.

Cite This Study

Dimitrakakis et al. (2000) studied this question.

synapsesocial.com/papers/6a707cdbf44fa9f079de2335 https://doi.org/10.1159/000054140

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Absence of Transplacental Passage of the Low Molecular Weight Heparin Enoxaparin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Absence of Transplacental Passage of the Low Molecular Weight Heparin Enoxaparin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider