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January 1, 1989Thrombosis and Haemostasis

Low Molecular Weight Heparin Novo (LHN-1) Does Not Cross the Placenta During the Second Trimester of Pregnancy

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Why the study?

Does low molecular weight heparin Novo (LHN-1) cross the placenta during the second trimester of pregnancy?

Population

27 women admitted for abortion during the second trimester of pregnancy. 7 women were excluded due to timing…

Comparison

Low molecular weight heparin Novo 35 anti-Xa… vs No LHN-1

Design

Cohort

Follow-up

3 to 7 hours

Authors

AOAbdelwahab OmriLaurentian UniversityJDJean-François DelaloyeSIB Swiss Institute of BioinformaticsHAHenning Boje AndersenTokyo Institute of Technology

Discussion

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Implication

May support LHN-1 for second-trimester anticoagulation; leaves open need for randomized fetal-outcome trials.

Structured PICO

Does low molecular weight heparin Novo (LHN-1) cross the placenta during the second trimester of pregnancy?

P
Population
27 women admitted for abortion during the second trimester of pregnancy (induced by application of prostaglandine PGE2 gel into the cervix). 7 women were excluded due to timing of expulsion, and 1 fetus was excluded due to failed blood collection.
I
Intervention
Low molecular weight heparin Novo (LHN-1) 35 anti-Xa units per kg of body weight via subcutaneous injection
C
Comparator
No LHN-1 (control group of 10 patients and their fetuses)
O
Outcome
Anti-Xa and anti-IIa levels in women and their fetusessurrogate

Low molecular weight heparin Novo (LHN-1) does not cross the placenta during the second trimester, suggesting it may be a safe alternative to unfractionated heparin for managing thromboembolic complications in pregnancy.

Cite This Study

Omri et al. (1989) studied this question.

synapsesocial.com/papers/6a707cdbf44fa9f079de2339https://doi.org/10.1055/s-0038-1646526
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Foetal Deaths from Antenatal Anticoagulant Therapy1955 · 45 citations
  2. 2Pregnancy in a patient with a prosthetic mitral valve. Associated with a fetal anomaly attributed to warfarin sodium1968 · 96 citations
  3. 3A Human Pharmacological Study Comparing Conventional Heparin and a Low Molecular Weight Heparin Fragment1985 · 85 citations
  4. 4Chondrodysplasia Punctata1975 · 140 citations