Key result
Maternal warfarin use for prosthetic mitral valve is linked to fetal nasal hypoplasia.
Why the study?
Pregnancy in patients with prosthetic mitral valves poses risks including potential fetal anomalies associated with warfarin sodium exposure.
Does warfarin sodium cause fetal anomalies in pregnant patients with prosthetic mitral valves?
Does warfarin sodium cause fetal anomalies in pregnant patients with prosthetic mitral valves?
Warfarin use during pregnancy in a patient with a prosthetic mitral valve was associated with fetal hypoplastic nasal structures, highlighting its teratogenic potential.
Answers are grounded in this paper and cite their sources.
Warfarin in pregnancy may cause nasal hypoplasia; leaves open optimal anticoagulation strategies for women with mechanical mitral valves.
Pregnancy in a patient with a prosthetic mitral valve was carried to term without any overt evidence of medical complications. The infant was born with hypoplastic nasal structures. Warfarin (Coumadin) sodium is suspected as the teratogenic agent.
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I. J. Kerber (1968) studied this question. Warfarin sodium use during pregnancy in a patient with a prosthetic mitral valve was associated with a fetal anomaly presenting as hypoplastic nasal structures.
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