Key result
Warfarin use during pregnancy for a prosthetic mitral valve is linked to infant nasal hypoplasia.
Why the study?
Pregnancy outcomes and potential teratogenic effects of warfarin in patients with prosthetic mitral valves are not well documented.
This case report highlights the suspected teratogenic effect of warfarin, resulting in hypoplastic nasal structures in an infant born to a mother with a prosthetic mitral valve.
Raises concern for warfarin teratogenicity in pregnancy; hypothesis-generating case report requiring validation in larger studies.
Pregnancy in a patient with a prosthetic mitral valve was carried to term without any overt evidence of medical complications. The infant was born with hypoplastic nasal structures. Warfarin (Coumadin) sodium is suspected as the teratogenic agent.
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Irwin J. Kerber (1968) studied this question. Warfarin use during pregnancy in a patient with a prosthetic mitral valve was suspected to cause hypoplastic nasal structures in the infant.
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