Population
Human voltage-sensitive sodium channel alpha-subunit (SCN4A gene) models
Comparison
Introduction of I1495F mutation vs Wild-type channels and T704M mutation
Design
Preclinical
Authors
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I1495F gating changes should not yet alter clinical management; extends mechanistic understanding of S5 segment roles in NaV1.4 channelopathies.
Identification of the novel I1495F mutation in the SCN4A gene reveals profound effects on sodium channel activation and inactivation, highlighting the role of the S5 segment.
Bendahhou et al. (1999) studied this question.
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