January 5, 2017PLoS ONEOpen Access

The Association between Polypharmacy and Dementia: A Nested Case-Control Study Based on a 12-Year Longitudinal Cohort Database in South Korea

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Why the study?

Does polypharmacy increase the risk of dementia in community-dwelling elderly patients?

Population

11,124 community-dwelling elderly patients aged ≥65 years with no prior hospitalization history from the…

Comparison

Polypharmacy vs Non-polypharmacy

Design

Case-control

Follow-up

2-year look-back period

Authors

HPHae‐Young ParkKorea Institute of Ocean Science and Technology JPJiwon ParkSt. Mary's Hospital HSHong Ji SongXuzhou Medical College

Discussion

Member takes

Implication

May support deprescribing trials in older adults; leaves open causal role in dementia incidence.

Structured PICO

Does polypharmacy increase the risk of dementia in community-dwelling elderly patients?

Population

11,124 community-dwelling elderly patients aged ≥65 years with no prior hospitalization history (5,562 newly diagnosed dementia cases and 5,562 matched controls) from the South Korean National Health Insurance Service sample cohort database.

Intervention

Polypharmacy (average use of ≥5 prescription drugs daily over a 2-year look-back period)

Comparator

Non-polypharmacy (<5 prescription drugs daily, with <1 drug used as reference in some analyses)

Outcome

Newly diagnosed dementia (defined by ICD-10 codes F00, F01, F02, F03, F051, G30, G311)hard clinical

Polypharmacy is significantly associated with an increased risk of dementia in the elderly, highlighting the need to limit inappropriate medication prescriptions.

Limitations

Multicollinearity may be a concern when assessing comorbidities which have high correlation in one model
Results of the association analysis depend on the statistical methods used

Cite This Study

Park et al. (2017) studied this question.

synapsesocial.com/papers/6a707ffbb27f158178276386 https://doi.org/10.1371/journal.pone.0169463

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The Association between Polypharmacy and Dementia: A Nested Case-Control Study Based on a 12-Year Longitudinal Cohort Database in South Korea

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The Association between Polypharmacy and Dementia: A Nested Case-Control Study Based on a 12-Year Longitudinal Cohort Database in South Korea

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider