Risk Factors and Outcomes of AKI after LAAC Operation: A Single-Center Observational Study from Mainland China

Lei Zhang; Jiarui Xu; Xiaoye Li; Xiaochun Zhang; Wenzhi Pan; Lihua Guan; Xiaoqiang Ding; Daxin Zhou; Junbo Ge

doi:10.31083/j.rcm2309306

September 9, 2022Reviews in Cardiovascular MedicineOpen Access

Risk Factors and Outcomes of AKI after LAAC Operation: A Single-Center Observational Study from Mainland China

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Why the study?

Predictors and prognosis of acute kidney injury occurrence among Chinese patients following left atrial appendage closure were not well established.

Structured PICO

P

Population

512 consecutive patients with paroxysmal or persistent nonvalvular atrial fibrillation (CHA2DS2-VASc ≥2, HAS-BLED ≥3, ineligible for long-term OAC), mean age 69, 60.2% male, from a single center in Mainland China. Excluded: LVEF ≤30%, moderate/severe mitral stenosis, left atrial thrombus, and concomitant interventional therapy.

I

Intervention

Left atrial appendage closure (LAAC) using Watchman or LAmbre device, performed under general anesthesia with fluoroscopy and transesophageal echocardiography guidance.

O

Outcome

Incidence of acute kidney injury (AKI) within 7 days after LAAC (defined by KDIGO criteria), and major adverse cardiovascular events (composite of all-cause mortality, readmission due to heart failure, cardiac surgery, systemic embolism, or bleeding events).composite

Limitations

Retrospective nature
Incidence of AKI could be underestimated because an AKI diagnosis after discharge may have been missed
Single-center, observational study

Abstract

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Cite This Study

Zhang et al. (2022) studied this question.

synapsesocial.com/papers/6a7080382163a0a01bc4b687 https://doi.org/10.31083/j.rcm2309306

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Risk Factors and Outcomes of AKI after LAAC Operation: A Single-Center Observational Study from Mainland China

Figures

Structured PICO

Limitations

Abstract

Discussion

Cite This Study

Risk Factors and Outcomes of AKI after LAAC Operation: A Single-Center Observational Study from Mainland China

Figures

Structured PICO

Limitations

Abstract

Discussion

Cite This Study

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