Key result
Multiparametric risk stratification improves SCD prediction in DCM beyond LVEF alone.
Why the study?
Current guideline-recommended SCD risk stratification in DCM relies heavily on LVEF to guide ICD therapy, despite limitations of single-parameter approaches and growing interest in multiparametric strategies.
Does a multiparametric risk stratification strategy improve the prediction of sudden cardiac death in patients with dilated cardiomyopathy compared to LVEF alone?
Does a multiparametric risk stratification strategy improve the prediction of sudden cardiac death in patients with dilated cardiomyopathy compared to LVEF alone?
Integrating advanced imaging, genetics, and clinical markers offers a more accurate, personalized approach to sudden cardiac death risk stratification in dilated cardiomyopathy than relying solely on LVEF.
May enhance SCD risk stratification in DCM beyond LVEF; leaves open prospective validation of multiparametric approaches.
Dilated cardiomyopathy (DCM) is one of the most common cardiomyopathy phenotypes. Moreover, sudden cardiac death (SCD) remains a leading cause of mortality in patients with DCM, predominantly driven by malignant ventricular arrhythmias (VAs). Current guideline-recommended risk stratification relies heavily on left ventricular ejection fraction (LVEF) to guide implantable cardioverter-defibrillator (ICD) therapy; however, attention has recently shifted toward a multiparametric strategy that integrates clinical characteristics with electrocardiographic markers, biomarkers, cardiac magnetic resonance (CMR) findings, genetic testing, and electrophysiological studies. This review summarizes current evidence on established and emerging tools for SCD risk stratification in DCM, highlights the limitations of single-parameter approaches, and discusses future directions toward more personalized, dynamic risk assessment to optimize SCD outcomes.
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Karanikola et al. (2026) conducted a review in Dilated cardiomyopathy. Multiparametric risk stratification vs. LVEF-based risk stratification was evaluated. Multiparametric risk stratification integrating clinical, imaging, and genetic markers improves sudden cardiac death prediction in dilated cardiomyopathy beyond left ventricular ejection fraction alone.
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