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October 14, 2003Endocrinology

Growth Hormone (GH)-Stimulated Insulin-Like Growth Factor I Gene Expression Is Mediated by a Tyrosine Phosphorylation Pathway Depending on C-Terminal Region of Human GH Receptor in Human GH Receptor-Expressing Ba/F3 Cells

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Why the study?

Does human GH stimulate IGF-I gene expression via a specific tyrosine phosphorylation pathway in Ba/F3-hGHR cells?

Population

Mouse pro-B, Ba/F3 cells stably expressing human GH receptor (Ba/F3-hGHR)

Comparison

Human GH with or without specific kinase… vs Untreated cells or cells without…

Design

Preclinical

Authors

HYHideo YoshizatoMTMinoru TanakaNNNaoya Nakai

Discussion

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Member takes

Overview

Does not alter GH-IGF-I clinical practice; leaves open a novel C-terminal hGHR tyrosine pathway in IGF-I regulation.

Structured PICO

Does human GH stimulate IGF-I gene expression via a specific tyrosine phosphorylation pathway in Ba/F3-hGHR cells?

P
Population
Mouse pro-B, Ba/F3 cells stably expressing human GH receptor (Ba/F3-hGHR)
I
Intervention
Human GH (0.01-10 nm) with or without specific kinase inhibitors (JAK2, MAPK, PI3K, genistein) or using a truncated C-terminal hGHR mutant (D351)
C
Comparator
Untreated cells or cells without inhibitors/mutations
O
Outcome
IGF-I gene expressionsurrogate

GH-stimulated IGF-I gene expression in Ba/F3 cells involves both the JAK-STAT5 pathway and a novel tyrosine phosphorylation pathway dependent on the C-terminal region of the human GH receptor.

Cite This Study

Yoshizato et al. (2003) studied this question.

synapsesocial.com/papers/6a7080dfac440176ef292a3ahttps://doi.org/10.1210/en.2003-0811
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