Key result
Exogenous growth hormone induced the expression of liver Igf-I mRNA in hypophysectomized male wild-type mice, but not in hypophysectomized male Stat5b(-/-) mice.
Population
Hypophysectomized male wild-type and Stat5b(-/-) mice
Comparison
Exogenous pulses of growth hormone (GH) vs Comparison between wild-type and Stat5b(-/-) mice
Design
Preclinical
Authors
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Does not support altering GH therapy; leaves open STAT5b as a therapeutic target pending human validation.
STAT5b plays an important and specific role in mediating GH-induced liver Igf-I gene expression.
Davey et al. (2001) studied this question. Exogenous pulses of GH vs. Wild-type vs Stat5b(-/-) mice was evaluated on Induction of Igf-I mRNA in livers. Exogenous growth hormone induced the expression of liver Igf-I mRNA in hypophysectomized male wild-type mice, but not in hypophysectomized male Stat5b(-/-) mice.
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