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February 14, 2008EndocrinologyOpen Access

Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression May Be Mediated by Multiple Distal Signal Transducer and Activator of Transcription 5 Binding Sites

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Population

Mouse liver and mouse genomic DNA (compared with human sequence)

Design

Preclinical

Key result

Growth hormone-induced STAT5 activation of IGF-I gene expression in the mouse liver is collectively mediated by at least eight STAT5 binding sites in distal intronic and 5'-flanking regions.

Authors

SESatyanaryana EleswarapuZGZhiliang GuHJHonglin Jiang

Discussion

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Overview

Does not alter clinical GH or IGF-I management; extends STAT5 regulatory mapping in murine liver.

Structured PICO

P
Population
Mouse liver and mouse genomic DNA (compared with human sequence)
I
Intervention
Growth hormone (GH) administration
O
Outcome
STAT5 binding to putative sites and IGF-I gene transcriptionsurrogate

Identifies multiple distal STAT5 binding sites that collectively mediate GH-induced IGF-I gene expression in the mouse liver.

Cite This Study

Eleswarapu et al. (2008) studied this question. Growth Hormone (GH) administration was evaluated on Identification and binding of STAT5 binding sites mediating GH-induced IGF-I gene expression. Growth hormone-induced STAT5 activation of IGF-I gene expression in the mouse liver is collectively mediated by at least eight STAT5 binding sites in distal intronic and 5'-flanking regions.

synapsesocial.com/papers/6a97ffb6d08ffd74dfc63c4ehttps://doi.org/10.1210/en.2007-1344
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1STAT5b Is Required for GH-Induced Liver Igf-I Gene Expression2001 · 40 citations
  2. 2STAT5b Is Required for GH-Induced Liver Igf-I Gene Expression2001 · 164 citations
  3. 3Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene.1996 · 90 citations
  4. 4Growth Hormone (GH)-Stimulated Insulin-Like Growth Factor I Gene Expression Is Mediated by a Tyrosine Phosphorylation Pathway Depending on C-Terminal Region of Human GH Receptor in Human GH Receptor-Expressing Ba/F3 Cells2003 · 15 citations
  5. 5Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo.1992 · 210 citations