Population
Rat insulinoma cell line RIN-5AH and COS7 cells
Design
Preclinical
Key result
Growth hormone stimulated rat insulin 1 promoter activity 2-fold by inducing the binding of STAT5 to a gamma-interferon-activated sequence-like element (Ins-GLE).
Authors
Loading...
May link GH to insulin transcription via STAT5; leaves open relevance to human islets or glucose homeostasis.
Effect estimate: 2-fold increase
Growth hormone stimulates insulin 1 promoter activity by inducing the binding of the transcription factor STAT5 to a specific element (Ins-GLE) in the rat insulin 1 gene.
Galsgaard et al. (1996) studied this question. Growth hormone (GH) was evaluated on Rat insulin 1 promoter activity (2-fold increase). Growth hormone stimulated rat insulin 1 promoter activity 2-fold by inducing the binding of STAT5 to a gamma-interferon-activated sequence-like element (Ins-GLE).