Why the study?
Does insulin regulate growth hormone gene transcription in rat pituitary cells?
Population
GH3 pituitary cells grown in serum-free defined medium
Comparison
Insulin treatment (0.7 nM to 7 nM) vs Control (no insulin)
Design
Preclinical
Follow-up
4 hours
Authors
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Does not alter GH therapy; leaves open insulin-pituitary transcription links in humans.
Does insulin regulate growth hormone gene transcription in rat pituitary cells?
This study demonstrates that insulin directly and rapidly suppresses the transcription of the growth hormone gene in rat pituitary cells.
Yamashita et al. (1986) studied this question.
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