Population
Murine 3T3-F442A pre-adipocytes and IRS- and GHR-deficient 32D cells stably reconstituted with rabbit GHR or…
Comparison
Growth hormone stimulation in cells expressing… vs Growth hormone stimulation in cells lacking IRS-1
Design
Preclinical
Authors
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No change to GH clinical practice; leaves open IRS-1 modulation of proliferative signaling for in vivo validation.
IRS-1 enhances growth hormone-induced proliferative signaling and mitogen-activated protein kinase activation in vitro.
Liang et al. (1999) studied this question.
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