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October 1, 1994Endocrinology

Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no alterations in deoxyribonucleic acid-protein interactions within the major promoter.

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Why the study?

Does growth hormone alter DNA-protein interactions within the major IGF-I promoter in hypophysectomized rats?

Population

Male juvenile hypophysectomized (hypox) rats

Comparison

Single ip injection of growth hormone (GH) vs Saline injection

Design

Preclinical

Follow-up

15, 30, 60, or 120 min

Authors

MTMichael J. ThomasKKKiyoshi KikuchiDBDavid P. Bichell

Discussion

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Overview

Constitutive promoter binding mediates GH effects on IGF-I in rats; leaves open precise activation mechanisms for further study.

Structured PICO

Does growth hormone alter DNA-protein interactions within the major IGF-I promoter in hypophysectomized rats?

P
Population
Male juvenile hypophysectomized (hypox) rats
I
Intervention
Single ip injection of growth hormone (GH)
C
Comparator
Saline injection
O
Outcome
DNA-protein interactions within the major rat IGF-I gene promoter (promoter 1) and 5'-untranslated region of exon 1surrogate

Growth hormone rapidly stimulates hepatic IGF-I transcription through constitutive DNA-protein interactions within the major promoter without altering these interactions.

Cite This Study

Thomas et al. (1994) studied this question.

synapsesocial.com/papers/6a8727f5f87adc0a02ca313ehttps://doi.org/10.1210/endo.135.4.7925121
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo.1992 · 210 citations
  2. 2Distinct Alterations in Chromatin Organization of the Two IGF-I Promoters Precede Growth Hormone-Induced Activation of IGF-I Gene Transcription2010 · 43 citations
  3. 3Rapid changes in gene expression after in vivo growth hormone treatment.1995 · 55 citations
  4. 4Transcriptional Regulation of Rat Insulin-Like Growth Factor-Binding Protein-1 Expression by Growth Hormone1990 · 68 citations
  5. 5Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene.1996 · 90 citations