Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
February 17, 2010Molecular EndocrinologyOpen Access

Distinct Alterations in Chromatin Organization of the Two IGF-I Promoters Precede Growth Hormone-Induced Activation of IGF-I Gene Transcription

View Full Paper
Ask AI
Bookmark
Share

Population

Pituitary-deficient young adult male rats (liver tissue)

Comparison

Single systemic growth hormone (GH) injection vs Absence of hormone (baseline)

Design

Preclinical

Follow-up

60 min

Key result

Systemic GH treatment caused an approximately 15-fold increase in transcription from each IGF-I promoter within 60 minutes, activating transcription by distinct promoter-specific mechanisms.

Authors

DCDennis J. ChiaJYJennifer J. YoungAMApril R. Mertens

Discussion

Loading...

Member takes

Overview

Should not change clinical GH use; hypothesis-generating for IGF-I promoter mechanisms in humans.

Structured PICO

P
Population
Pituitary-deficient young adult male rats used to investigate the chromatin landscape of the IGF-I gene in the liver.
I
Intervention
Single systemic growth hormone (GH) injection
C
Comparator
Absence of hormone (baseline)
O
Outcome
Chromatin organization of the IGF-I promoters and IGF-I gene transcription in the liversurrogate

Main Result

Effect estimate: 15-fold increase

Growth hormone induces rapid changes in hepatic chromatin at the IGF-I locus, activating transcription via distinct promoter-specific mechanisms.

Cite This Study

Chia et al. (2010) studied Pituitary deficiency. Systemic GH injection vs. Absence of hormone was evaluated on Transcription from each IGF-I promoter (15-fold increase). Systemic GH treatment caused an approximately 15-fold increase in transcription from each IGF-I promoter within 60 minutes, activating transcription by distinct promoter-specific mechanisms.

synapsesocial.com/papers/6a9f62ca3c7dd4a18968fff2https://doi.org/10.1210/me.2009-0430
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo.1992 · 210 citations
  2. 2Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no alterations in deoxyribonucleic acid-protein interactions within the major promoter.1994 · 48 citations
  3. 3Rapid changes in gene expression after in vivo growth hormone treatment.1995 · 55 citations
  4. 4Minireview: Mechanisms of Growth Hormone-Mediated Gene Regulation2014 · 121 citations
  5. 5Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression May Be Mediated by Multiple Distal Signal Transducer and Activator of Transcription 5 Binding Sites2008 · 61 citations