February 1, 2003Journal of EndocrinologyOpen Access

Insulin restores GH responsiveness during lactation-induced negative energy balance in dairy cattle: effects on expression of IGF-I and GH receptor 1A

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Population

14 Holstein cows in early lactation (starting day 10 postpartum)

Comparison

Hyperinsulinemic-euglycemic clamp for 96 h vs Saline infusion for 96 h

Design

Preclinical

Follow-up

96 hours

Authors

Discussion

May support insulin use in early-lactation dairy cattle; leaves open relevance to human GH-IGF-I regulation.

Population

14 Holstein cows in early lactation (starting day 10 postpartum)

Intervention

Hyperinsulinemic-euglycemic clamp (insulin i.v. 1 micro g/kg body weight per h) for 96 h

Comparator

Saline infusion for 96 h

Outcome

Plasma IGF-I and GH concentrations, and hepatic expression of total GH receptors, GH receptor 1A (GHR 1A), and IGF-Isurrogate

Insulin administration during early lactation in dairy cattle restores GH responsiveness and increases circulating IGF-I concentrations.

Butler et al. (2003) studied this question.

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