Why the study?
Does initial combination therapy with macitentan and tadalafil improve cardiopulmonary haemodynamics and functional capacity in newly diagnosed PAH patients?
Does initial combination therapy with macitentan and tadalafil improve cardiopulmonary haemodynamics and functional capacity in newly diagnosed PAH patients?
Initial combination therapy with macitentan and tadalafil is well tolerated and improves haemodynamics and functional capacity in newly diagnosed PAH patients.
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May support initial dual therapy in new PAH; hypothesis-generating pending randomized confirmation.
Sitbon et al. (2020) studied this question.
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