Why the study?
What are the clinical and laboratory features of venous limb ischemia/gangrene complicating cancer in patients treated with warfarin for DVT?
What are the clinical and laboratory features of venous limb ischemia/gangrene complicating cancer in patients treated with warfarin for DVT?
Warfarin can induce severe venous limb ischemia/gangrene in cancer patients due to a failure to block hypercoagulability while causing severe protein C depletion.
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Warfarin-associated VLG in occult cancer warrants diagnostic vigilance; this Level 3 observation leaves open optimal anticoagulation strategies in malignancy.
Warkentin et al. (2015) studied this question.
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